The Releve comprehensive joint formula is designed to support joint health in a more complete and scientific fashion. Releve contains glucosamine to help support joint health, but Releve's main mechanism of action in supporting healthy joints is its patented COX-2 inhibiting ingredient IsoOxygene. Releve employs a number of other benefits to help support joint health and bone health. Releve also contains substances that regulate the expression of enzymes in the cells that make bone.