We all need strong bones... it's the difference between living young and being old. But calcium alone is not enough. And many of us can't take prescription drugs because of adverse side effects.

But now there's OsteoValin™... the all new, all natural, non-drug, non-prescription bone-health breakthrough.

If your doctor told you not to take Fosamax or Boniva because of possible side effects... don't be discouraged.

Ask your doctor about OsteoValin. OsteoValin not only helps prevent bone deterioration, it actually helps your body build new bone mass... Stay strong, upright and active...

OSTEOVALIN™ AND BONE: ANATOMY AND PHYSIOLOGY OF THE SKELETON

Approximately 30% of an oral dose of the OsteoValin active mineral, when administered alone, is absorbed via both vitamin-D dependent active transport and passive diffusion mechanisms in the intestine. 90% of absorbed OsteoValin mineral is excreted by the kidney, while 10% is excreted via the fecal stream. The kidney preferentially excretes the mineral over calcium due to increased tubular resorption of the later cation. The human body contains approximately 4.6 mg of the OsteoValin mineral per kg body weight; bone, teeth, and connective tissue contain 99% while the remaining 1% is found primarily in muscle, fat, and skin. The mineral is a bone-seeking element due to its chemical similarity to calcium.

The skeleton is the body’s organ of structural support. In addition to holding up the body’s contents, the skeleton provides an anchor for muscles and serves as a lever and pivot for muscle action. The skeleton protects the body’s cavities, the cranium, thorax, and abdomen. The skeleton houses the bone marrow, where the cellular constituents of blood are made. The skeleton is also a reservoir for essential body chemicals, including calcium, phosphate, and sodium. 20% of the weight of living bone is water.

The skeleton consists primarily of bone, and bone consists of two forms: compact bone and trabecular bone. Compact bone is the dense outer shell of the skeleton, while trabecular bone consists of plates, rods, arches, and struts of bone contained within compact bone. Both compact and trabecular bone are made from protein and mineral. Bone is strong and hard because calcium phosphate crystals, hydroxyapatite, are deposited around the protein matrix.

OsteoValin’s™ key element can substitute for calcium in hydroxyapatite. Hydroxyapatite is similar to limestone, and bone can be thought of as stone crystals held together by proteins. The element exchanges with calcium in already formed hydroxyapatite crystals within bone mineral and is incorporated directly into newly formed bone.

Bone is a living and dynamic material. With repeated use and over time, bone sustains micro damage and needs to be renewed or replaced. The process of replacing old and damaged bone is called remodeling. The bone cells responsible for remodeling are osteoblasts and osteoclasts. The process of remodeling is initiated by osteoclasts excavating out old and damaged bone, followed by osteoblasts filling in the excavated bone with new bone. Osteoclast activity followed by osteoblast activity in remodeling is tightly linked and is referred to as coupling. All the bone in the body is turned over every six years.

As mentioned above, the key OsteoValin mineral can replace calcium in the mineral crystals, hydroxyapatite, in bone. OsteoValin’s effects on bone are to inhibit osteoclasts, that is to decrease the excavation of old bone, and to stimulate osteoblasts so that new bone is made. The key OsteoValin mineral uncouples bone remodeling. No longer is bone made only following bone resorption; new bone is made independent of bone resorption. The net effect is an increase in bone. The mineral stimulates the process of bone building. The presence of the active OsteoValin mineral in bone correlates with bone compression strength.

Teeth are similar in composition to bone, as both contain calcium hydroxyapatite crystals. OsteoValin can replace calcium in teeth as it does in bones. A number of epidemiologic observations have linked the concentration of the active OsteoValin element in food and to the prevalence of caries (cavities). Among naval recruits, recruits from northwestern Ohio, northeastern South Carolina, and west central Florida had no evidence of caries and this appeared to correlate with the concentration of the mineral in drinking , cooking , and vegetables eaten. In Slovenia, the concentration of the mineral in soil, drinking , and dental enamel correlated with resistance to caries among schoolchildren. Administering the OsteoValin mineral to rats prevents the development of caries in these animals. These observations suggest that a deficiency of the mineral predisposes humans to caries.

The molecular effects of the mineral on bone are mediated by the cellular calcium receptor. All mammals have an exquisitely sensitive system to maintain blood calcium levels within a very narrow range. This system involves cell types in organs throughout the body, including bone, kidney, parathyroid, thyroid, and the small intestine. The cells in this system have receptors on their cell surface which respond to the extracellular calcium concentration and trigger specific cellular responses. OsteoValin™ mimics the effects of calcium on this cell membrane calcium sensing mechanism, but only when there is a sufficiently high concentration of the mineral. Because 99% of the body’s mineral supply is found in bone, a mineral concentration sufficient to activate the calcium receptor can only be achieved in bone. This may account for the specificity of the OsteoValin mineral’s effect on osteoblastic activity.